Region

The machining order proceeds according to regions, rather than by layers. Using Region for core parts reduces air movements, thus reducing machining time.
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Extended Region

This is similar to the Regions option, but uses a different method of defining regions, resulting in a looser definition of a region.

Layer

Machine by constant layers. The cutter path will skip regions if necessary and return to these regions when a complete constant Z layer is completed.
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Region & Layer

If a part includes both core and cavity areas, the core areas will be milled by layer and the cavity areas will be milled by region. This is particularly useful when two or more cavity areas are situated close to one another.
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(For 3D Volume Milling and Surface Milling > By Layer procedures. You must not select Volume and Pass Separately.)